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创新固相肽合成(SPPS)协议:为疏水抗菌肽合成开辟绿色新路径
固相肽合成(SPPS)溶剂消耗大,环境负担重。研究人员开展了改良标准 SPPS 协议合成疏水聚集肽的研究。结果显示新方法减少了溶剂消耗,且合成的 P3 抗菌活性与粘菌素标准相当。该研究为可持续合成疏水肽提供新思路。
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