Predicting a protein's structure from its amino acid sequence is a 'holy grail' for the structural biology community ... the alignment correct at such low levels of sequence identity is a ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

We show here that these diverse peptide sequences bind with comparable affinities to the Numb PTB domain at a common binding site on the surface of the protein. The NMR structure of the Numb PTB ...

have solved the structure of a protein that has stumped scientists for more than 10 years. And they did so from the comfort of their own homes, playing on online protein folding game called Foldit.

1 These dynamic, ever-changing proteins have long fallen through the cracks of conventional structural biology methods ... appreciate that protein structure is a spectrum. (3) While some proteins ...