Lissencephaly is a devastating genetic disease of children that affects the embryonic development of the brain. It is caused by haploinsufficiency of the Lis1 gene product, which seems to be ...

The roundworm Caenorhabditis elegans is revealing the molecular glitch behind a rare brain disorder. In lissencephaly – Greek for "smooth brain" – the cerebral cortex lacks characteristic convolutions ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

Lissencephaly refers to a rare condition in which the brain's typical folds do not develop, and brain development is disrupted. People with the condition often have intellectual disability and ...