The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development.

AMPK signaling promotes an increase in cell stiffness that drives ... been shown to promote the growth of Ras-mutant pancreatic cancers, and may be an important pathway that drives cancer progression ...

Announcing a new article publication for BIO Integration journal.   Diabetes, a common metabolic condition, poses a substantial health burden worldwide. To revolutionize diabetes management, enhance ...

They report that it works through the lysosomal AMPK-activating pathway, which amps up AMPK in response to low cellular glucose. The signaling pathway relies on the vacuolar H+-ATPase (V-ATPase), ...

AMPK controls signaling pathways that postpone aging, including FOXO proteins and TORC1. AMPK also stimulates the formation of nicotinamide adenine dinucleotide (NAD+), which activates ...