While tau has an important neurophysiological function, when it undergoes pathological changes and accumulates in the brain, this protein has been found to contribute to some neurodegenerative ...

Numerous proteins involved in the adenosine triphosphate (ATP) metabolism showed independent associations with tau accumulation and tangles and were differentially abundant in the neurons.

“The main takeaway is that subtle changes in brain activity, linked to amyloid-beta and tau protein buildup, occur long before noticeable symptoms of Alzheimer’s disease,” Baillet told PsyPost.