"Our findings reveal that the basal ganglia—a brain circuit regulating adaptive behavior and motor functions—is affected in autism, with disruptions in how dopamine and acetylcholine work ...

In the eIF4E mice, acetylcholine binding to dopamine axons was impaired, leading to less calcium influx. Increasing calcium restored dopamine release, showing that the problem lies in nicotinic ...

Miwa’s initial work showed that lynx1 was concentrated in the nervous system. Additional studies in collaboration with Ibañez-Tallon showed that lynx-1 altered the function of nicotinic acetylcholine ...