研究人员针对 miR-218 在原发性 AEL 的作用开展研究，发现其影响细胞增殖凋亡，与 CTNND2 和 MAPK 通路有关。 急性红白血病（Acute erythroid leukemia，AEL）是一种罕见的急性髓系白血病（Acute myeloid leukemia，AML）亚型，侵袭性很强，预后较差。值得注意的是，红系分化 ...

However, we found that most acute myeloid leukemia (AML) cells, especially M4 and M5 subtypes, produce TNF and show basal level activation of RIP1/RIP3/MLKL signaling, yet do not undergo necroptosis.

Despite many advances made in the understanding of leukemia biology, therapy for acute myelogenous leukemia (AML) has remained essentially unchanged for 40 years and is, too often, debilitating ...