to induce donor-specific T-cell-mediated cytotoxic responses and trigger acute rejection of an allogeneic skin graft. The indirect allorecognition pathway is required for B-cell activation and ...

Both pathways are important in mechanisms of allograft rejection. It is thought that the direct pathway is responsible for acute rejection and that the indirect pathway is responsible for chronic ...

Here, we found that treatment with hu5C8 alone prevented the development of acute allograft rejection in outbred rhesus monkeys without any conventional immunosuppression and without any apparent ...

Early acute rejection following lung transplantation can be safely detected and graded by transbronchial biopsy via bronchoscopy.

Recent advances using transgenic animals or exogenous complement inhibitors have demonstrated prevention of hyperacute rejection of vascularized organs, but not graft loss due to acute vascular ...

University of Manchester scientists have discovered that removing immune cells from donor hearts using a new technique can reduce the risk of acute rejection after heart transplant surgery - even ...

The FDA issued a dreaded Complete Response Letter rejecting the therapy intended for paediatric steroid-refractory acute graft versus host disease. In the letter the FDA asked for at least one ...

The kidney transplant rejection prophylaxis market is projected to experience steady growth, driven by the introduction of innovative therapi ...

Pseudomonas aeruginosa triggers lung transplant rejection by killing regulatory T cells, revealing new targets for AMR ...

With the current study, the Vienna Lung Transplant Program has pioneered the use of ECP and applied it to the treatment of acute and chronic rejection reactions as well as certain antibody problems.