However, we found that most acute myeloid leukemia (AML) cells, especially M4 and M5 subtypes, produce TNF and show basal level activation of RIP1/RIP3/MLKL signaling, yet do not undergo necroptosis.

Orca-T demonstrated a lower incidence of severe acute GvHD and non-relapse mortality compared to alloHSCT ... Treatment with the T-cell immunotherapy Orca-T improved survival free of ...

More information: Jason Xu et al, A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia, Nature Cancer (2024). DOI ...