肿瘤治疗电场（TTFields）已用于治疗多种癌症，但部分患者疗效不佳。为探究原因，研究人员开展 TTFields 与 PI3K/AKT 通路关系的研究。结果发现 PI3K/AKT 通路参与癌细胞对 TTFields 的反应，抑制该通路可增敏。这为提升 TTFields 疗效提供新思路。

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

The review explores strategies to overcome this resistance, focusing on targeting downstream molecules within the RAS-RAF-MEK-ERK and PI3K-AKT-mTOR ... the Notch signaling pathway, essential ...

The review explores how signaling disruptions inside tumor ... of BC cases exhibit variations that hyperactivate the PI3K/Akt/mTOR pathway, underscoring its critical role in oncogenesis." ...