Spironolactone is a nonselective aldosterone antagonist, and eplerenone is selective to the aldosterone receptor. Although numerous clinical trials have evaluated the efficacy of each drug ...

Other recent outcome studies document that resistant hypertension is not rare. In the Controlled ONset Verapamil INvestigation of Cardiovascular End Points trial (CONVINCE), [2] more than 16,600 ...

Significant hyperkalemia did contribute to sudden cardiac death. Note that unfractionated heparin also has aldosterone antagonist effects.

investigated whether adding the aldosterone receptor antagonist spironolactone to renin–angiotensin system inhibition improved proteinuria in patients with diabetic nephropathy. Patients with ...

"Excess levels of aldosterone are associated with hypertension ... a dual endothelin receptor antagonist (ERA) submitted for approval in the US last month that has been tipped as a potential ...