This review discusses the role of aldosterone antagonists in the treatment of heart failure, including an overview of aldosterone’s role in the pathology of heart failure, the benefits of each ...

Spironolactone and eplerenone are life-saving agents for patients with advanced heart failure and may benefit patients with mild heart failure. Patients' potassium levels and renal function must ...

The aldosterone antagonist eplerenone was evaluated in the Epleronone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) trial, leading to the recommendation for ...

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in ...

Heart failure is a syndrome ... [Hurst’s The Heart Section 11:13a,14a-b,15a] Although the renin-angiotensin-aldosterone system is activated in HFpEF, it is not as prominent as with systolic ...

For people with heart failure (HF), the long-presumed benefits of fluid restriction did not pan out in the FRESH-UP ...

It’s classified as a potassium-sparing diuretic and an aldosterone antagonist. Spironolactone is approved by the Food and Drug Administration (FDA) to treat heart failure, particularly severe ...

This study offers hope for individuals with uncontrolled and treatment-resistant high blood pressure. Lorundrostat, a new drug that targets a hormone called aldosterone, has shown promise in ...