Amino acid metabolism involves the synthesis, breakdown, and interconversion of amino acids in the body. Excess amino acids that are not used for protein synthesis can be catabolized to produce energy ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

The results were published in Nature Metabolism. The study ... Furthermore, the scientists showed that one amino acid - leucine - seems to have a disproportionate role in driving the pathological ...