More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038/s41467 ...

We begin by taking another look at key catabolic pathways in the cell including glycolysis, the Krebs cycle and mitochondrial electron transfer; before considering fatty acid β-oxidation and the ...

The UAB researchers found that HIF1α-glycolysis is indispensable for IFN-γ induction in hypoxic T cells. HIF1α is a subunit of HIF, or hypoxia-inducible factor, that is known to play a crucial ...