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PAK5-mediated PKM2 phosphorylation is critical for anaerobic glycolysis in endometriosis
Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the ...
Medical Xpress10d
Study reveals potential therapeutic target for endometriosis
By targeting PAK5, it may be possible to modulate PKM2 activity and subsequently affect anaerobic glycolysis, a critical process in endometriosis. These findings not only advance the understanding ...
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An energy trap for tumor cells: Researchers find enzyme blockade halts liver cancer growth
Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been thought to depend on the energy obtained through glycolysis ...
News Medical11d
Targeting PAK5 could offer new therapeutic approach for endometriosis
By targeting PAK5, it may be possible to modulate PKM2 activity and subsequently affect anaerobic glycolysis, a critical process in endometriosis. This study's contributions to the field are ...
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HIF1α identified as crucial for T cell activation in oxygen-poor tumors
More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038/s41467 ...