Angiotensin II (AT-II)-Receptor Antagonists are Reviewed. Research focused on blocking the renin- angiotensin system (RAS) led to the discovery of angiotensin-converting-enzyme (ACE) inhibitors ...

In clinical studies of irbesartan there was no relationship between the dosage and the overall frequency of adverse reactions. The rates of serious adverse events were similar for irbesartan (1.0% ...

In patients given ACE inhibitors, add-on ARB therapy might inhibit the activity of angiotensin II produced via ACE-independent pathways. On the other hand, in patients on ARB therapy, ACE ...