Antibodies, also known as immunoglobulins (IGs), are glycoproteins produced in response to an immune reaction and exhibit high specificity for the antigens that elicit the response. An antibody ...

The structure of the ROR1-binding arm of the bi-specific antibody in complex with ROR1 was determined by X-ray crystallography. Disclaimer: AAAS and EurekAlert! are not responsible for the ...

Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.

“Protein structure can change in the culture condition — we need to look at their ever-shifting states, not just a snapshot.” Initial images have already shown that antibody structures ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

This image accompanied the report "Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site," by J. Bostrom et. al. appearing in the March 20, 2009 issue of ...