Antifungal development is inherently difficult, in part because humans and fungi share similar eukaryotic cellular machinery, and so identifying targets that are selectively found in fungi poses ...

Human fungal pathogens exemplify a severe threat to health due to their complex infection strategies and the host's immune system's failure to eradicate ...

In the case of antifungals, they include molecular changes in the drug target itself; overexpression of the drug target—thus swamping the antifungal agent; the reverse of overexpression ...

Fungal and human cells are more similar than bacterial and human cells, making finding antifungal targets with minimal toxicity to humans difficult. Because of this, only several antifungals that ...

which is necessary for polyenes to perform their antifungal activity Antagonism Change in composition of target by one antifungal Next administration of another antifungal agent becomes ...

(IN BRIEF) Basilea Pharmaceutica Ltd announced that its antifungal drug, Cresemba® (isavuconazole), surpassed sales targets in Japan, triggering a CHF 1.2 million sales milestone payment from its ...

(IN BRIEF) Basilea Pharmaceutica Ltd announced that its antifungal drug, Cresemba® (isavuconazole), surpassed sales targets in Japan, triggering a CHF 1.2 million sales milestone payment from its ...