Recent structures of the Runx1–CBFβ heterodimer bound to DNA brings to six the number ... and p53 (a pair of antiparallel β-strands). This first loop sits in the major groove and makes ...

The OB domain consists of a five-stranded antiparallel beta barrel plus an alpha helix ... The NTase domain binds to the broken and intact DNA strands in the major groove flanking the nick and also in ...

Atomic force microscope–based single-molecule force spectroscopy was employed to measure sequence-dependent mechanical properties of DNA by stretching individual DNA double strands attached ...

DNA strands are held together by delicate hydrogen bonds between the bases in a base pair. The "double helix" of DNA refers ...

The findings, published in Nature Structural & Molecular Biology, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands. By unveiling Pol-theta's ...