Nucleases can cleave stalled forks, causing double-strand breaks (DSBs) to form and activate ataxia-telangiectasia mutated (ATM). The rate at which DSBs form at stalled forks is greatly increased ...

Herein, we focus on the effects of acute versus chronic hypoxia and hypoxic cellular adaptation on the ATM (ataxia telangiectasia mutated) and/or ATR (ataxia telangiectasia and Rad3-related ...

The Schmitt family is grateful for the resources through A-T Children’s Project, as well as the love and care at St. Jude’s, ...

each triggered by different types of DNA lesions and coordinated by either ataxia-telangiectasia mutated (ATM) or IRAK1 kinases.” “This discovery could have significant implications for cancer ...

"We had previously demonstrated that the p53 gene product--the most commonly mutated gene in human cancer--controls cell-cycle arrest in response to damage," says Kastan. In this paper the authors ...

announced the online publication of safety data from patients with Ataxia-Telangiectasia (A-T) treated with EryDex for a minimum of 24 months in Frontiers in Neurology. "A-T is a rare pediatric ...

The newly allowed application covers the method of treating patients with Ataxia-Telangiectasia and provides patent coverage for preparing erythrocytes loaded with one or more substances of ...