Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

This research focuses on how the mTOR pathway influences key renal cells ... of mTOR contributes to kidney injury by inhibiting autophagy, increasing oxidative stress, and promoting inflammation.