In an exclusive interview with PEOPLE, Jay and Pamela — both born with osteogenesis imperfecta, or brittle bone disease — ...

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It’s estimated more than 10 million Americans over the age of 50 live with this "silent disease." Here's what osteoporosis ...

Related: Jay & Pamela: Couple with Brittle Bone Disease Thrive Despite Limited Mobility: 'You Don't Use It, You Lose It' (Exclusive) Never miss a story — sign up for PEOPLE's free daily ...

Worryingly, the brittle-bone disease is no longer an illness that strikes only middle-aged women. American research has found that osteoporosis affects teenagers and women in their 20s.

Jay Manuel, 28, and Pamela Chavez, 30, were both born with osteogenesis imperfecta type 3 — often called brittle bone disease. The rare genetic bone disorder makes people more susceptible to breaking ...

“Jay & Pamela”: Couple with Brittle Bone Disease Thrive Despite Limited Mobility: 'You Don't Use It, You Lose It' (Exclusive) ...

Jay Manuel, 28, and Pamela Chavez, 30, were both born with osteogenesis imperfecta type 3 — often called brittle bone disease. The rare genetic bone disorder makes people more susceptible to ...

Malformations of collagen are among the primary causes of genetic disorders, such as brittle bone disease, where some affected individuals experience fractures with minimal force, while others ...