We first studied the effects of high- fat diet (HFD) on Cd28KO, then on wild-type (WT) mice treated with an inhibitor of CD28/B7 interactions, CTLA4-Ig. We report that Cd28KO displayed larger ...
CD28 is the major co-stimulatory receptor in T cells which, upon binding ligand, induces sustained T-cell proliferation and cytokine production when combined with T-cell receptor stimulation.
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