Nature9 年
Recurrent activating mutations of CD28 in peripheral T-cell lymphomas
We found increased transcription of the CD28-responsive genes CD226 and TNFA in cells expressing the T195P mutant in response to CD3 and CD86 co-stimulation and increased downstream activation of ...
Nature9 年
CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice
The CD28 costimulatory molecule is required for ... thick sections of ATs were incubated with antibodies directed against CD3 (Dako, Glostrup, Denmark) or F4/80 (Serotec, Raleigh, NC, USA).
technologynetworks10 个月
GMP Human 4-1BB Ligand Protein for T, NK, and DC Cell Culture
Conventionally, the first and second stimulation signals in vitro, simulating the process in vivo, are achieved using anti-CD3 antibody, anti-CD28 antibody, or CD3/CD28 magnetic beads, along with the ...