Epigenetic modifications are heritable but plastic, thereby allowing cells to modify their gene expression patterns in response to changing contexts, as CD4 + T cells do in response to infection ...

Treated recipients received either 3 mg/kg rapamycin intraperitoneally for the first 14 d after transplantation (days 0-13) and/or 0.25 mg/dose CD40L-specific ... γ-secreting T cells were ...