在本次研究中，康涅狄格大学团队则专门设计了仅分析肿瘤新抗原特异性CD8 + T细胞的实验系统，并根据CD8 + T细胞的TCR亲和力高低进行分类，再分别 ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

胰腺癌——“癌中之王”，因其高度恶性和极差的预后让人望而生畏。研究揭示，肿瘤微环境中效应CD8+ T细胞的缺失与功能失活是胰腺癌免疫逃逸和治疗抵抗的核心原因，但其调控机制尚未完全解析。因此，探索胰腺癌肿瘤微环境效应 CD8+ T ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

A groundbreaking study published in Nature reveals how tissue-resident memory CD8 T cells in the small intestine take on ...

A recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8 + T cell division for the generation of memory precursor cells.

Immunotherapy, cancer treatments that alter the immune system, making it better apt to fight tumor cells, have provided novel and efficacious therapeutic o | Cancer ...

Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme – P4HA1 prolyl hydroxylase, is strongly induced in CD8+ T cells in solid cancer, the primary immune ...

Proper immune system function is paramount for human survival against infectious disease ... Once acquired infection persists for life requiring continuous life long cellular immunity (CD8 memory T ...