A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

CRISPR-Cas9 is a precision genome editing technology that can knock out, activate or fine-tune the expression of individual genes. We provide access to CRISPR KO (knockout), CRISPRi (interference ...

CRISPR/Cas9, a groundbreaking gene-editing technology, holds the potential to transform oilseed production in Kashmir ...

Horizon has created a library of ready-made isogenic human cell line pairs edited using CRISPR-Cas9 technology. With 10,000 gene targets available — 3,000 of them off-the-shelf — the knockout ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

Both gene knockout and knock-in models are powerful ... regularly interspaced short palindromic repeats (CRISPR)/associated ...

This will allow quicker and easier gene knock-down experiments, for example, because having on-board Cas9 makes more room in vectors used to deliver the guide RNA to contain multiple instructions for ...

In about a third of patients, the gene for dystrophin has small deletions or single base mutations that render it nonfunctional, which makes this gene an excellent candidate for gene editing.

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

In the spring, five patients with sickle cell disease began treatment with Casgevy, the first FDA-approved CRISPR-Cas9 gene editing treatment. The therapy—which involves removing blood stem ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...