The stromal-derived factor-1 (SDF-1)/CXCR4 axis is a major determinant in the crosstalk between leukemic cells and BM stroma. In this study, we investigated the use of AMD11070, an orally ...

Because the levels of total cellular CXCR4 as assessed by western blotting ... treated cells fail to normally internalize the CXCR4 receptor in the presence of SDF-1α produced by the MEFs.

The molecular interactions between CXCR4 inhibitors or antagonists with the CXCR4 receptor have been examined primarily using three methods. The first method involves examining the effect of CXCR4 ...

The discovery of HIV coreceptors, such as CCR5 and CXCR4, has prompted a search for inhibitors against these receptors as an alternative therapy to HAART. Although new anti-HIV drugs that target ...

5 in Nature Communications. The researchers discovered that a receptor called Cxcr4, when blocked in mice, reduced the tendency of fat stem cells to develop into white fat, also called white ...

Microscopy analysis showed the X4-2-6 peptide did not alter the colocalization of the CXCR4 receptor with beta-arrestin 2 (BA2) in an immortal T cell line. This material relates to a paper that ...

EMA validates X4 Pharma’s marketing authorization application for mavorixafor to treat WHIM syndrome: Boston Monday, January 27, 2025, 11:00 Hrs [IST] X4 Pharmaceuticals, a comp ...

Submission supported by positive results from global, Phase 3 4WHIM clinical trial; U.S. regulatory approval in WHIM syndrome granted in 2024 Decision on MAA expected in 1H 2026 BOSTON, Jan. 24, 2025 ...

First, Carlsten’s team focused on a receptor that binds the molecule E-selectin ... FUT7-engineered NK cells were better at traveling to the bone marrow than unmodified NK cells. Adding the CXCR4 ...