The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

4). Protease digestion or heat treatment abrogated the chemokinetic activity of BMCM, and pretreating T cells with pertussis toxin or antibody against CXCR4 caused an inhibition of bi-directional ...

"This did indeed lead to a significant reduction in CD8 + T cell migration into atherosclerosis plaques," affirms Duchêne, "suggesting that the CXCL12–CXCR4 signaling pathway plays a key role ...

"This did indeed lead to a significant reduction in CD8+ T cell migration into atherosclerosis plaques," affirms Duchêne, "suggesting that the CXCL12-CXCR4 signaling pathway plays a key role in ...