X inactivation only occurs in cells with multiple X chromosomes, which explains why almost all calico cats are female. X inactivation exists in two different forms: random and imprinted.

Dilute calico cats owe their coloration to a fascinating genetic interaction. Like all calicos, dilute calicos are almost exclusively female: the gene for coat color is located on the X chromosome.

Conversely, calico or tortoiseshell cats are usually female – the female’s extra X chromosome allows the possibility of her receiving both a black and orange gene. 1. https://be.chewy.com ...

Meet Khloe! This 13-year-old long hair calico princess came to Animal Friends when her owner was unable to care for her.

while almost all calico cats are female. That’s because in cats, unlike most other animals, the genes for sex and hair color are located on the same chromosome, the X chromosome. However ...