G protein–coupled receptors (GPCRs) are one of the most popular target classes investigated in the drug-discovery process. With its selection of kits (cAMP femto, cAMP dynamic and cAMP HiRange ...

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However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein–coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs ...