it is now highly debated whether polydendrocytes are multipotential cells that can give rise to neurons and astrocytes as well as oligodendrocytes. Recent findings from in vivo fate-mapping ...

CellRank 2: unified fate mapping in multiview single-cell data. Weiler P*, Lange M*, Klein M, Pe’er D, Theis F. Nat Methods. 2024 Jun 13. PMID: 38871986. The covariance environment defines cellular ...

In the past few years, however, an ever-expanding set of tools for single-cell analysis has allowed researchers to track each cell’s fate as it happens—by focusing on embryonic development in animal ...

My research leverages stem cells and induced cell fate change to study early development with a focus on epigenetics and post-transcriptional regulation. During both development and homeostasis, ...

outlines a single-cell epigenome-wide map that could aid the study of human cell fate determination. "Our recent paper in Nature Neuroscience was inspired by the need to better understand the ...

The team observed how FRCs develop through cell fate-mapping analyses and tested what happens when they remove them from tumors in mice. This helped assess the role of FRCs in the immune system's ...

Despite the importance of cell extrusion in development and aging, as well as its pathological importance in cancer progression, the cues which determine the fate of an extruded cell were ...

Tang and Anna Vähärautio, a cancer biologist at the University of Helsinki and coauthor of the study, wanted to develop a method that combined lineage tracing—the process of tracking cell fate and ...

Optical labeling techniques allow scientists to observe cell behavior, track cell fate, and identify cells with specific traits. While fluorescent proteins are widely used for these purposes ...