许多雌性动物的器官会因繁殖而进行重构。利用小鼠的肠道作为研究器官大小调整的一个易于处理的模型发现繁殖诱导的重构是预见性的，并且与饮食或微生物群诱导的大小调整不同。基于此，2025年3月20日，英国弗朗西斯·克里克研究所 Irene ...

肠道重塑的特异性 ：肠道重塑并非由饮食摄入增加或微生物群变化被动导致。怀孕早期肠道的伸长和黏膜重塑先于食物摄入量的增加，且无菌小鼠在生殖过程中肠道仍会发生重塑，补充益生菌也不影响肠道的生殖性生长，表明肠道重塑是生殖状态特异性的。 转录和空间变化 ...

Sometimes it’s easy to tell if something is living or not. A teddy bear might look like a bear, but it cannot do any of the seven things it needs to be able to do to count as being alive.

Even then, only limited numbers of spermatogonia enter meiosis at any one time, such that adult males retain a pool of actively dividing spermatogonia that acts as a stem cell population.

This produces a new cell called a zygote, which will mature into an embryo. The number of cells increase by mitosis, and as the embryo develops, the cells begin to differentiate (or specialise).

The five phases of mitosis and cell division tightly coordinate the movements of hundreds of proteins. How did early biologists unravel this complex dance of chromosomes? The most obvious ...

"These cells co-develop together, just like they would in an actual embryo, and establish that history of being neighbors," ...

Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating ...

Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This ...

Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This ...

A team of stem cell scientists successfully spawned mice from two male parents that reached adulthood, a significant step, but they still have to figure out the mechanics of the gene modification.

ID GSE266025. The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision. ID PXD052193. differentially expressed proteins (DEPs) at the blastocyst stage in the ...