靶向脂质代谢：针对脂质沉积和 FAO 异常等问题，他汀类药物、雷帕霉素、过氧化物酶体增殖物激活受体 γ（Peroxisome Proliferator-Activated Receptor γ，PPARγ）激动剂等药物在动物模型研究中显示出抑制 PF 的效果，但部分药物的安全性和有效性还存在争议9。 靶向线粒 ...

Touch a hot plate and your hand flies back. While the response is almost instant, researchers are still working to better ...

Meibomian glands are critical to the ocular health in that they secrete lipid-rich meibum, which protects the ocular surface ...

Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.

Science Signaling is a weekly journal, publishing 51 issues a year, as well as an online resource and information management tool that enables experts and novices in cell signaling to find ...

CD8+ T cells accumulate in atherosclerotic plaques. LMU researchers identify a crucial signaling pathway - with therapeutic potential.

as a key regulator of meibomian gland stem cell proliferation and tissue regeneration. They found that increased Hh signaling ...

CAR-T cell therapy is currently used successfully ... Cochrane et al, High-affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells, Molecular ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Reference: Barnes SA, Thomazeau A, Finnie PSB, et al. Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives dendritic spine plasticity and reverses fragile X ...

Myeloid cells constitute essential components within the immunosuppressive microenvironment of various tumors, significantly influencing cancer progression ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...