In contrast, blood vessel organoids did not express these molecules before integrating into the cerebral organoids. To assess the barrier integrity of the assembloids, Guo and his team measured ...

“Even the most complex organ—the human brain—can start to form without any micro-manipulation.” Knoblich cautioned that the organoids are not “brains-in-a-jar.” “We’re talking about the very first ...

Organoids, or self-organizing miniature organs, represent a powerful new tool to study organogenesis or model diseases and are considered a means to generate cells and tissues for cell ...

Compound Responsiveness: Cardiac organoids react to substances, which makes it easier to evaluate drugs for safety and efficacy and to conduct pharmacological research. Matrigel-Free: Cerebral ...

The Xu laboratory works on developing human stem cell models to study the underlying mechanisms of human neurological disorders, such as Alzheimer's disease, and apply these models for drug screening.

More information: Anbin Chen et al, Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids, Advanced Science (2024). DOI: 10.1002/advs.202307136 ...

Using a large-scale library of TC organoids they developed, the researchers performed comprehensive comparative analyses of chemo-sensitive and chemo-resistant cells. Their efforts shed light on ...