Now, Bernhagen and colleagues, writing in Nature Medicine, have identified MIF as a ligand for the CXC-chemokine receptors CXCR2 and CXCR4, and suggest that targeting MIF could be used as an ...
The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...
Researchers from Sun Yat-Sen University and affiliated organizations presented data from a study that aimed to investigate mechanisms by which the CXC chemokine receptor 3 (CXCR3) antagonist, AMG-487, ...
Anti-eosinophil approaches include targeting cytokines (anti-IL-4, -13, and -5), their receptors (βc) or chemokine receptors (CCR3). Anti-IL-4 and -IL-13 therapies and TP1 ASM-8 (a CCR3/βc ...
Chemokines are a subclass of cytokines, a large family of small secreted proteins that communicate via G protein-coupled heptahelical chemokine receptors on the cell surface. Atrial fibrillation ...