The complement cascade is a biochemical process in the blood that helps or 'complements' cells of the immune system to eliminate invading pathogens. When activated by one of three pathways ...

Signs and symptoms of age-related macular degeneration (AMD) are important to spot to prevent further deterioration of sight.

Mass General Brigham researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery ...

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system-a group of proteins that ...

To determine whether C1q has a role in synapse elimination, the authors examined mice deficient in C1q (C1qa-knockout mice), in which the complement cascade cannot be activated. Defects in synapse ...

Herein, GZMK was found to act as complement cascade-activating protease to promote inflammatory responses. GZMK cleaves many complement components including C2, C3, C4 and C5, which collectively ...

By targeting C3, SYFOVRE is designed to provide comprehensive control of the complement cascade, part of the body’s immune system. SYFOVRE is approved in the United States and Australia. About Apellis ...

Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery.