Cdk activity can be reduced in the absence of cyclin degradation. Cdk inhibition in the absence of CycB degradation caused cells to exit from mitosis (that is, initiate early events of cell ...

This normally also degrades the Cdk1 activator cyclin B. If the researchers next prevented cyclin B degradation or expressed non-degradable cyclin B and then washed out the Cdk1 inhibitors, the cells ...

DOI: 10.1038/s41467-024-55669-x Rebecca Schunk et al, A phosphate-binding pocket in cyclin B3 is essential for XErp1/Emi2 degradation in meiosis I, EMBO Reports (2025). DOI: 10.1038/s44319-024-00347-8 ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...