New structural findings on APE1–DNA cocrystals provide insights into ... it coordinates potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic representation ...

DNA is susceptible to damage caused by errors committed during replication and by environmental factors, such as radiation, oxidants, or alkylating agents. Repair reactions involve the excision of ...

DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...

and the inability of the base excision repair pathway to handle the damage to DNA that this induces. Five of the conditions (xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy ...

And its DNA repair comes from its ability to stimulate base excision repair. As per experts, when we protect our DNA, it means that we are reducing the risk of cancer, slowing down the aging ...

Their results suggest that DNA damage itself serves as the checkpoint ... More information: Aris A. Polyzos et al, Base excision repair and double strand break repair cooperate to modulate ...

Cells have evolved various DNA repair mechanisms to correct such mutations. One such mechanism is base excision repair (BER), where the mutated adenine is recognized and removed by DNA glycosylases, ...