Apurinic/apyrmidinic endonuclease 1 (APE1) plays a central role in DNA repair by cleaving the ... potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic ...

(A) Common DNA damaging agents (top), examples ... respectively (both induced by UV light); BER and NER, base- and nucleotide-excision repair, respectively; HR, homologous recombination; EJ ...