Cells employ an arsenal of editing mechanisms to correct mistakes made during DNA replication. How do they work, and what happens when these systems fail?

Mutations can occur when adenine is altered or mismatched with other bases. For example, the deamination of adenine can lead to the formation of hypoxanthine, which can pair with cytosine instead of ...

This reaction, deamination, is about twice as ... Sequencing (PER-seq), to sequence over 28 billion bases across more than 130 million DNA molecules, measuring the accuracy of both normal human ...