本文研究揭示了在DNA损伤修复和癌症进展过程中EZH2的功能微调PARP1活性背后的分子机制，这就为联合靶向作用EZH2和PARP1从而治疗癌症提供了一定的 ...

In contrast to PARP1 and PARP2, neither PARP10 nor the predicted PARP-family mART enzymes are thought to be activated by DNA damage. In fact—at least in vitro—DNA reduces PARP10 activity 7.

The PARP & DDR Inhibitors Summit will equip you ... community to optimize & expand current DDR inhibitors including ATR, DNA-PK, PolQ & Rad51 target novel synthetic lethal pairs & develop safe ...

This serves two main functions. First, it allows PARP proteins to maintain functionality by returning them to their inactive forms. PARG inhibition results in increases in sensitivity to DNA damage ...

东京国家癌症中心研究所基因组应激信号实验室等多单位的研究人员 Kimiyoshi Yano、Megumi Kato 等，在《Cell Death Discovery》期刊上发表了题为 “PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ...

DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

Normal metabolic activity produces reactive oxygen species (ROS) that, if not eliminated, can damage cellular components. As a result, ROS from overactive mitochondria are frequently cited as a source ...

Enzymes called DNA damage response kinases and tubulin acetyltransferase ... triple negative breast cancer is a class of ...

Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study by the University of Copenhagen and Nanyang Technological University, Singapore, reveals that RNA ...