They can also be produced when DNA replication forks encounter DNA single-strand breaks or other types of lesion. They can occur at the termini of chromosomes due to defective metabolism of ...

Shrivastav, M. et al. Regulation of DNA double-strand break repair pathway choice. Cell Research 18, 134–147 (2008). Singh, R. K. & Krishna, M. DNA strand breaks signal the induction of DNA ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...

Scientists have provided the most detailed account yet of the earliest stages of DNA replication, an essential process for ...

More information: Xinzhe Tang et al, In vitro reconstitution of meiotic DNA double-strand-break formation, Nature (2025). DOI: 10.1038/s41586-024-08551-1 Provided by Chinese Academy of Sciences ...

For DNA to replicate, the helix must first unwind and break the DNA from a double strand into two single strands. Upon binding, helicases melt the DNA, breaking the chemicals bonds holding the ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

In addition to Lander and Zerio, authors of the study, "Human polymerase θ helicase positions DNA microhomologies for double-strand break repair," include Yonghong Bai, Brian A. Sosa-Alvarado and ...

In addition to Lander and Zerio, authors of the study, "Human polymerase θ helicase positions DNA microhomologies for double-strand break repair," include Yonghong Bai, Brian A. Sosa-Alvarado and ...