随着基因编辑技术的飞速发展，研究人员看到了治疗线粒体疾病的新曙光。近年来，一种新兴的基因编辑工具——转录激活因子样效应子连接的脱氨酶 (Transcription activator-like effector-linked deaminase, ...

including a series of biochemical pathways called DNA repair. These include three discrete pathways for the excision of damaged bases, called base excision repair, mismatch repair and nucleotide ...

DNA is susceptible to damage caused by errors committed during replication and by environmental factors, such as radiation, oxidants, or alkylating agents. Repair reactions involve the excision of ...

Sunburns and aging skin are obvious effects of exposure to harmful UV rays, tobacco smoke and other carcinogens. But the effects aren't just skin deep. Inside the body, DNA is literally being torn ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

For the past several years, researchers at Georgia State University tapped into the Summit supercomputer at the Department of Energy's Oak Ridge National Laboratory to study an elaborate molecular ...

Open’s bonnet, takes a deep breath and says, “It will cost you.” Scientists have harnessed the Summit supercomputer's raw computational muscle to examine how cells repair DNA damage. Using Summit’s ...

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights ...

But as they age, they accumulate more and more DNA damage. Until now, it has been unclear why the cell's repair mechanisms do not fix the damage. Researchers led by Melina Schuh and Ninadini ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

Human polymerase θ helicase positions DNA microhomologies for double-strand break repair. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-025-01514-8 Cite This Page : ...