In contrast, yeast DNA ligase IV is not essential for cell growth. However, deletion of the LIG4 gene elicits phenotypes indicating that ligase IV catalyzes the repair of double-strand breaks in the ...

Causes: LIG4 syndrome is caused by a mutation in the LIG4 gene, which carries the instructions needed to make a protein known as DNA ligase 4. This protein is an enzyme that helps repair a ...

Genes exist in most cells. Inside a cell is a long strand of the chemical DNA (deoxyribonucleic acid). A DNA sequence is a specific lineup of chemical base pairs along its strand. The part of DNA ...