He hopes to unravel many more mysteries of the enzymes involved in DNA repair and beyond. “We’ve gained some interesting and unexpected insights into how BRCA2 behaves. That only came from ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

"We also want to understand why Pol-theta exists in its tetrameric form and how it interacts with other DNA repair enzymes," says Lander. "Such insights could lead to new ways of targeting BRCA ...

"We also want to understand why Pol-theta exists in its tetrameric form and how it interacts with other DNA repair enzymes," says Lander. "Such insights could lead to new ways of targeting BRCA ...

RNA repair enzymes capable of sealing 2’,3’-cyclic-PO 4 /5’-OH breaks or 3’-OH/5’-PO 4 breaks are present in diverse taxa in all phylogenetic domains of life. ATP-dependent RNA ligases join 3’-OH and ...

After that, it's in the hands of the surgeon - the PInC - in the third and final stage of repair. With the "patient" stabilized and prepped for surgery, the operation to remove the damaged DNA strand ...

"We also want to understand why Pol-theta exists in its tetrameric form and how it interacts with other DNA repair enzymes," says Lander. "Such insights could lead to new ways of targeting BRCA ...

Together with Tabrizi’s study, the findings converge on the idea that MSH3 and other DNA mismatch repair enzymes accelerate CAG expansion, and thus degeneration, in HD-vulnerable neurons. Both Tabrizi ...