Guarding genes against damage is a crucial and complex job, so it’s to be expected that cells have several mechanisms to repair DNA breakages, each providing support under different circumstances.

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Hypoxic cells can acquire a mutator phenotype that consists of decreased DNA repair, an increased mutation rate and increased chromosomal instability. Defects in homologous recombination and ...

4 Given their roles in DNA replication and repair, it is unsurprising that scientists have targeted both PARP and PARG for anticancer efforts. 2,4 Here, PARylation is an indicator of approach efficacy ...