How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail? Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body ...

Cells employ an arsenal of editing mechanisms to correct mistakes made during DNA replication. How do they work, and what happens when these systems fail?

UCLA Health researchers say study findings uncover Huntington's disease mechanisms and pave new ways to develop treatments.

Base editing corrected a mutation that causes macular degeneration, highlighting the potential of gene therapy to treat ...

The DNA repair and replication pathways converge on a common final step in which the continuity ... site that abolish the capacity to form the ligase-adenylate intermediate also eliminate nick ...

However, how the mutation causes the disease remains poorly ... However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease ...

This process is mutagenic and can give rise to cancer. LA JOLLA, CA—DNA repair proteins act like the body’s editors, constantly finding and reversing damage to our genetic code. Researchers ...

But as they age, they accumulate more and more DNA damage. Until now, it has been unclear why the cell's repair mechanisms do not fix the damage. Researchers led by Melina Schuh and Ninadini ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

Human polymerase θ helicase positions DNA microhomologies for double-strand break repair. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-025-01514-8 Cite This Page : ...

These large, mysterious creatures are the longest-living vertebrates on the planet—and their genomes could contain clues to how they prevent cancer and reach such an advanced age ...