Structure Maintenance of Chromosome (SMC) complexes are central to chromosome segregation, compaction and DNA repair, thereby impacting on gene expression and regulation. SMC family members that ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post ...

Recent research has begun to clarify the enzymology of DNA DSB repair pathways and has indicated key roles for these pathways in preventing mutations, chromosomal instability and cancer.

PARylation is integral to many key cellular functions, including signaling modulation and DNA repair. PARylation is reversible and is undone by PAR erasers such as poly ADP-ribose glycohydrolase (PARG ...

"We found that the manner in which tumor cells die after radiotherapy depends on the engagement of specific DNA repair ...

"Pol-theta is an important target, and many pharmaceutical companies see it as a promising way to treat cancers that have ...

Cancers with DNA repair deficiencies depend on other proteins to provide backup pathways for DNA repair, which allows the cancer cells to proliferate fast and survive despite DNA damage.