The breakdown in this ongoing dance of DNA damage and repair is one of the root causes ... have few effective treatment options outside of surgery, and it's not uncommon for these tumors to ...

How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail? Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body ...

"The surprising result of our research is that DNA repair, which normally protects healthy cells, determines how cancer cells die following radiotherapy," said Prof Cesare. "The DNA inside our ...

Neoadjuvant Keytruda for patients with deficient DNA mismatch repair colon cancer resulted in a pathological complete ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...

A data analysis from a randomized clinical trial for stage 3 colon cancer patients by investigators at Dana-Farber Brigham ...